Atr^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Atr^tm1Bal
• Name: ataxia telangiectasia and Rad3 related; targeted mutation 1, David Baltimore
• MGI ID: MGI:2176600
• Synonyms: ATR-
• Gene: Atr Location: Chr9:95739650-95833834 bp, + strand Genetic Position: Chr9, 50.27 cM, cytoband E4
• Alliance: Atr^tm1Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60768
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the first three exons was replaced with a neomycin resistance cassette. (J:60768)

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atr^tm1Bal

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atr Mutation: 133 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas) or J1 (129S4/SvJae).

References

• Original: J:60768 Brown EJ, et al., ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 2000 Feb 15;14(4):397-402
• All: 13 reference(s)