Atr^tm1Akl
Targeted Allele Detail

Summary

• Symbol: Atr^tm1Akl
• Name: ataxia telangiectasia and Rad3 related; targeted mutation 1, A de Klein
• MGI ID: MGI:2176604
• Gene: Atr Location: Chr9:95739650-95833834 bp, + strand Genetic Position: Chr9, 50.27 cM, cytoband E4
• Alliance: Atr^tm1Akl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61732
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An nls-lacZ gene and thymidine kinase/neomycin resistance cassette was inserted in frame just 5' to the sequences encoding the most highly conserved part of the kinase domain. (J:61732)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atr Mutation: 133 strains or lines available

References

• Original: J:61732 de Klein A, et al., Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol. 2000 Apr 20;10(8):479-82
• All: 2 reference(s)