Fhit^tm1Hbn
Targeted Allele Detail

Summary

• Symbol: Fhit^tm1Hbn
• Name: fragile histidine triad gene; targeted mutation 1, Kay Huebner
• MGI ID: MGI:2176611
• Synonyms: Fhit^-, Fhit^tm2KCC
• Gene: Fhit Location: Chr14:11307738-12919681 bp, + strand Genetic Position: Chr14, 5.61 cM, cytoband A2
• Alliance: Fhit^tm1Hbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61946
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A termination codon, a GFP gene and a loxP flanked neomycin selection cassette were inserted into exon 5. Immunoblot analysis showed that homozygous mouse tissues were entirely negative for the encoded protein, and immunohistochemical detection in kidney sections of homozygous mice showed absence of the protein. (J:61946)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fhit^tm1Hbn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fhit Mutation: 22 strains or lines available

References

• Original: J:61946 Fong LY, et al., Muir-torre-like syndrome in fhit-deficient mice. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4742-7
• All: 14 reference(s)