Tfap2a^tm1Will
Targeted Allele Detail

Summary

• Symbol: Tfap2a^tm1Will
• Name: transcription factor AP-2, alpha; targeted mutation 1, Trevor Williams
• MGI ID: MGI:2176682
• Synonyms: AP-2 -, AP-2alpha-, AP-2alpha-deficient
• Gene: Tfap2a Location: Chr13:40868778-40891852 bp, - strand Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
• Alliance: Tfap2a^tm1Will page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33031
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a geonomic fragment containing exon 6 and the first three nucleotides of exon 7, deleting sequences encoding the dimerization domain of the protein. (J:33031)

Disease models

Expression

In Mice Carrying this Mutation:	26 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	43 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2a Mutation: 39 strains or lines available

References

• Original: J:33031 Zhang J, et al., Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature. 1996 May 16;381(6579):238-41
• All: 17 reference(s)