Tfap2c^tm1Hsc
Targeted Allele Detail

Summary

• Symbol: Tfap2c^tm1Hsc
• Name: transcription factor AP-2, gamma; targeted mutation 1, Hubert Schorle
• MGI ID: MGI:2176695
• Synonyms: AP2gamma^loxP, conditional AP-2gamma, Tfap2c^fl
• Gene: Tfap2c Location: Chr2:172391513-172400542 bp, + strand Genetic Position: Chr2, 94.87 cM, cytoband H3-H4
• Alliance: Tfap2c^tm1Hsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75122
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted 5' to exon 5 and a loxP flanked neomycin and thymidine kinase selection cassette was inserted 3' to exon 5. The neomycin and thymidine kinase selection cassette was removed in ES cells by Cre mediated recombination prior to the production of chimeric mice, leaving loxP sites flanking exon 5 in the final allele. (J:75122)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2c Mutation: 28 strains or lines available

References

• Original: J:75122 Werling U, et al., Conditional inactivation of transcription factor AP-2gamma by using the Cre/loxP recombination system. Genesis. 2002 Feb;32(2):127-9
• All: 8 reference(s)