Bcl2l1^tm1Mam
Targeted Allele Detail

Summary

• Symbol: Bcl2l1^tm1Mam
• Name: BCL2-like 1; targeted mutation 1, Lothar Hennighausen
• MGI ID: MGI:2176699
• Synonyms: fl^neo
• Gene: Bcl2l1 Location: Chr2:152622588-152673648 bp, - strand Genetic Position: Chr2, 75.41 cM, cytoband H1
• Alliance: Bcl2l1^tm1Mam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63161
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: This hypomorphic allele was generated by the insertion of a loxP flanked neomycin resistance cassette 5' to exon 1 in the promoter and a single loxP site 3' to exon 2. RT-PCR experiments demonstrated a down-regulation in transcript expression in gonads. (J:63161)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l1 Mutation: 104 strains or lines available

References

• Original: J:63161 Rucker EB 3rd, et al., Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol Endocrinol. 2000 Jul;14(7):1038-52
• All: 10 reference(s)