Bdnf^tm3Jae
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm3Jae
• Name: brain derived neurotrophic factor; targeted mutation 3, Rudolf Jaenisch
• MGI ID: MGI:2176750
• Synonyms: Bdnf², Bdnf^2L, Bdnf^2lox, Bdn^flox, Bdnf^tm2Jae
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm3Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71969
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted 5' to the only coding exon, and a loxP-flanked hygromycin resistance cassette was inserted 3' to the exon. The hygromycin selection cassette was removed in ES cells by transient Cre expression leaving a single loxP site prior to the production of chimeric mice. (J:71969)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:71969 Rios M, et al., Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol. 2001 Oct;15(10):1748-57
• All: 107 reference(s)