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Tg(Camk2a-cre)93Kln
Transgene Detail
Summary
Symbol: Tg(Camk2a-cre)93Kln
Name: transgene insertion 93, Rudiger Klein
MGI ID: MGI:2176754
Synonyms: CamK-cre93, CaMKII-Cre93, CaMKII-CRE (93), Ck-cre, cre93
Transgene: Tg(Camk2a-cre)93Kln  Location: unknown  
Alliance: Tg(Camk2a-cre)93Kln page
Transgene
origin
Strain of Origin:  CBA/J
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Camk2a-cre)93Kln expression driven by 1 gene
 
Mutation detailsThis transgene directs the expression of Cre recombinase under the control of the calcium/calmodulin-dependent protein kinase II promoter. The promoter is active starting at P21 in the cortex, hippocampus, hypothalamus and brainstem, but not in glia. (J:58229)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Camk2a (species not specified)
Summary of all recombinase alleles driven by Camk2a.
 

Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
cn1  Disease Model
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J
 
cn2  Disease Model
involves: 129S4/SvJae * C57BL/6 * CBA/J
 
involves: 129S4/SvJae * C57BL/6 * CBA/J
 
involves: 129S4/SvJae * C57BL/6 * CBA/J
 
involves: 129S4/SvJae * CBA/J
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
       
behavior/neurological
N
behavior/neurological phenotype
N
lethargy
polyphagia
increased aggression towards male mice
increased anxiety-related response
limb grasping
ataxia
decreased locomotor activity
hyperactivity
growth/size/body
obese
increased body length
increased susceptibility to age related obesity
homeostasis/metabolism
abnormal homeostasis
increased circulating glucose level
increased circulating insulin level
increased circulating leptin level
insulin resistance
increased cholesterol level
mortality/aging
premature death
nervous system
decreased brain weight
abnormal hippocampus CA2 region morphology
abnormal olfactory bulb morphology
abnormal neuron morphology
abnormal action potential
reproductive system
reduced female fertility
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
cn1
cn2
IDs
Expression
In Mice Carrying this Mutation: 3 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:58229 Minichiello L, et al., Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 1999 Oct;24(2):401-14
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory