Casr^tm1Ces
Targeted Allele Detail

Summary

• Symbol: Casr^tm1Ces
• Name: calcium-sensing receptor; targeted mutation 1, Christine Seidman
• MGI ID: MGI:2176758
• Synonyms: CaR^-, Casr-
• Gene: Casr Location: Chr16:36314058-36382503 bp, - strand Genetic Position: Chr16, 25.57 cM
• Alliance: Casr^tm1Ces page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29900
• Parent Cell Line: C1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 4. Western blot analysis on kidney protein membrane extracts from homozygous mice confirmed that no detectable protein is expressed from this allele. RT-PCR analysis of chondrocytes from homozygous mice detected the presence of a smaller transcript lacking exon 5. In addition protein expression is detected in the growth plates of homozygous mice. (J:29900, J:129678)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casr Mutation: 61 strains or lines available

References

• Original: J:29900 Ho C, et al., A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism [see comments]. Nat Genet. 1995 Dec;11(4):389-94
• All: 32 reference(s)