Nf1^tm1.1Par
Targeted Allele Detail

Summary

• Symbol: Nf1^tm1.1Par
• Name: neurofibromin 1; targeted mutation 1.1, Luis F Parada
• MGI ID: MGI:2176764
• Synonyms: Nf1-, Nf1delta
• Gene: Nf1 Location: Chr11:79230519-79472438 bp, + strand Genetic Position: Chr11, 46.74 cM, cytoband B4-5
• Alliance: Nf1^tm1.1Par page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68558
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Nf1^tm1Par. Exons 31 and 32 were deleted via Cre mediated recombination. This was achieved by mating mice carrying the NF1^tm1Par mutation to mice carrying Egr2^tm2(Cre)Pch (strain 129S2/SvPas). This deletion is heritable, and is transmitted through the germ line. (J:68558)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nf1 Mutation: 161 strains or lines available

References

• Original: J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
• All: 8 reference(s)