Lepr^tm1Rck
Targeted Allele Detail

Summary

• Symbol: Lepr^tm1Rck
• Name: leptin receptor; targeted mutation 1, Jeffrey M Friedman
• MGI ID: MGI:2176774
• Synonyms: LepR^fl, ObR^flox
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm1Rck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72241
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted 5' to exon 1 and a loxP-flanked neomycin and thymidine kinase selection cassette was inserted 3' to exon 1. The selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. leaving a single loxP site 3' to exon 1 in the final allele. (J:72241)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:72241 Cohen P, et al., Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest. 2001 Oct;108(8):1113-21
• All: 50 reference(s)