Lepr^tm1.1Rck
Targeted Allele Detail

Summary

• Symbol: Lepr^tm1.1Rck
• Name: leptin receptor; targeted mutation 1.1, Jeffrey M Friedman
• MGI ID: MGI:2176775
• Synonyms: ObR^delta
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm1.1Rck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72241
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Lepr^tm1.1Rck in which exon 1 and flanking sequences were deleted in the germline by crossing mice carrying this allele to mice carrying Tg(EIIa-Cre)1Lmgd. (J:72241)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:72241 Cohen P, et al., Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest. 2001 Oct;108(8):1113-21
• All: 2 reference(s)