Il6st^tm1Kish
Targeted Allele Detail

Summary

• Symbol: Il6st^tm1Kish
• Name: interleukin 6 signal transducer; targeted mutation 1, Tadamitsu Kishimoto
• MGI ID: MGI:2176787
• Synonyms: gp130 -
• Gene: Il6st Location: Chr13:112600604-112643394 bp, + strand Genetic Position: Chr13, 63.73 cM
• Alliance: Il6st^tm1Kish page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75419
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin selection cassette was inserted into exon 2. (J:75419)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6st Mutation: 80 strains or lines available

References

• Original: J:75419 Yoshida K, et al., Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):407-11
• All: 7 reference(s)