Tg(Nes-cre)1Atp
Transgene Detail

Summary

• Symbol: Tg(Nes-cre)1Atp
• Name: transgene insertion 1, Andreas Trumpp
• MGI ID: MGI:2176835
• Synonyms: Nes-Cre1, Nestin^cre, Nestin-Cre, Tg(Nes-cre)1Mrt
• Transgene: Tg(Nes-cre)1Atp Location: unknown
• Alliance: Tg(Nes-cre)1Atp page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Nes-cre)1Atp expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Nes (25491)

  Nes	(MGI:101784)

• Mutation details: The 5' region of the rat nestin gene was placed upstream of an NLS-Cre-pA and the rat nestin intron 2. This line carried a single or low copy transgene. The absence of transcript expression was confirmed by RT-PCR on endoneurial extracts. This promoter is active by E9 in the CNS progenitor cells. Transgene is paternally imprinted, thus brain-specific recombination is only 30% when allele is maternally inherited, compared to ~95% with paternal transmission (J:75417, J:121563). (J:58999, J:111945)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities Alliance rat Nes gene page

Disease models

Expression

In Mice Carrying this Mutation:

131 assay results 1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Nes-cre)1Atp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:58999 Trumpp A, et al., Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 1;13(23):3136-48
• All: 81 reference(s)