Stheal3^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Stheal3^MRL/MpJ
• Name: soft tissue heal 3; MRL/MpJ
• MGI ID: MGI:2176956
• QTL: Stheal3 Location: Chr4:45658442-45658566 bp Genetic Position: Chr4, cM position of peak correlated region/allele: 24.16 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased wound healing compared to SJL/J. (J:73197)
• Inheritance: Other (see notes)

Notes

Stheal3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73197

Genome scan at a resolution of 15 cM was performed on 633 (MRL/MpJ x SJL/J)F2 animals to identify QTLs associated with wound healing at different time intervals. Parental strain MRL/MpJ exhibits complete healing of ear hole wounds whereas SJL/J animals heal approximately 25% of the wound. Significant QTLS affecting soft tissue healing, Stheal1-9, were mapped to 6 different mouse chromosomes. Stheal1 maps to 49.2 cM on mouse Chromosome 1 spanning 36.9 cM - 81.6 cM with a maximum LOD score of 7.06 at D1Mit334. MRL/MpJ-derived alleles confer increased wound healing in a dominant fashion at Stheal1. Stheal2 maps to 63.1 cM on mouse Chromosome 3 spanning 49.7 cM - 78.5 cM with a maximum LOD score of 6.18 at D3Mit217. MRL/MpJ-derived alleles confer increased wound healing in a dominant fashion at Stheal2. Stheal3 and Stheal4 map to 17.9 cM and 51.3 cM on mouse Chromosome 4, respectively. The peak LOD score of Stheal3 is centered at D4Mit214 (LOD=7.26) and the peak LOD score of Stheal4 is centered at D4Mit31 (LOD=6.82). MRL/MpJ-derived alleles confer additively-inherited increase in wound healing at Stheal3 and Stheal4. Stheal5 maps to 37 cM on mouse Chromosome 6 with a peak LOD score of 4.5 at D6Mit261. MRL/MpJ-derived alleles confer additively-inherited increase in wound healing at Stheal5. Stheal6 and Stheal7 map to 52.4 cM and 66 cM on mouse Chromosome 7 with peak LOD scores of 4.84 and 4.26 at D7Mit220 and D7Mit12, respectively. SJL/J-derived alleles confer increased wound healing in a dominant fashion atStheal6 while MRL/MpJ-derived alleles confer additively-inherited increase in wound healing at Stheal7. Stheal8 and Stheal9 map to 33 cM and 43 cM on mouse Chromosome 9 with peak LOD scores of 14.18 and 16.11 at D9Mit207 and D9Mit270, respectively. MRL/MpJ-derived alleles confer additvely-inherited increase in wound healing at Stheal8 and Stheal9. A suggestive QTL, Stheal10, mapped to 65 cM on mouse Chromosome 13 with LOD=3.03 at D13Mit228. Authors note that Stheal6 and Stheal10 maybe identical to wound healing QTLs Heal6 and Heal8, respectively, identified by McBrearty et al. LOD scores at all QTLs did not vary significantly with respect to time interval.

References

• Original: J:73197 Masinde GL, et al., Identification of Wound Healing/Regeneration Quantitative Trait Loci (QTL) at Multiple Time Points that Explain Seventy Percent of Variance in (MRL/MpJ and SJL/J) Mice F(2) Population. Genome Res. 2001 Dec;11(12):2027-33
• All: 1 reference(s)