Dmc1^Mei11
Chemically induced Allele Detail

Summary

• Symbol: Dmc1^Mei11
• Name: DNA meiotic recombinase 1; spermatogonial depletion
• MGI ID: MGI:2177010
• Synonyms: sgdp
• Gene: Dmc1 Location: Chr15:79445698-79489310 bp, - strand Genetic Position: Chr15, 37.79 cM, cytoband E
• Alliance: Dmc1^Mei11 page

Histopathology of Dmc1^Mei11/Dmc⁺ mouse testes

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60747
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Nucleotide substitutions
• Mutation details: This mutation was identified in an EMS mutagenesis screen for recessive infertility. Two consecutive base changes have been identified at positions 968-969 of the gene transcript. These changes result in an Alanine to Proline amino acid change in a putitive DNA binding structure..
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmc1 Mutation: 17 strains or lines available

References

• Original: J:60747 Munroe RJ, et al., Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet. 2000 Mar;24(3):318-21
• All: 3 reference(s)