Cebpa^tm1Gjd
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm1Gjd
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 1, Gretchen J Darlington
• MGI ID: MGI:2177053
• Synonyms: Cebpa-, c/ebpalpha^m1
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm1Gjd page

Lack of mature neutrophils in Cebpa^tm1Gjd/Cebpa^tm1Gjd mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28320
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic DNA fragment containing the entire gene and 2.4 kb of flanking sequences. (J:28320, J:91859)

Expression

In Mice Carrying this Mutation:	159 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 19 strains or lines available

References

• Original: J:28320 Wang ND, et al., Impaired energy homeostasis in C/EBP alpha knockout mice. Science. 1995 Aug 25;269(5227):1108-12
• All: 33 reference(s)