Socs1^tm2Wehi
Targeted Allele Detail

Summary

• Symbol: Socs1^tm2Wehi
• Name: suppressor of cytokine signaling 1; targeted mutation 2, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:2177057
• Synonyms: SOCS-1delta
• Gene: Socs1 Location: Chr16:10601672-10603400 bp, - strand Genetic Position: Chr16, 5.81 cM
• Alliance: Socs1^tm2Wehi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72528
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Homologous recombination is used to generate an allele where only the SOCS box of the gene is deleted. (J:72528)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs1 Mutation: 30 strains or lines available

References

• Original: J:72528 Zhang JG, et al., The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action invivo. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13261-5
• All: 1 reference(s)