Cebpa^tm1Gonz
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm1Gonz
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 1, Frank Gonzalez
• MGI ID: MGI:2177133
• Synonyms: C/EBPalpha^f, c/ebpalpha^fl
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm1Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42995
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted 40 bp downstream of the translation start site of the gene and a loxP-flanked neomycin cassette was inserted 1.8 kb downstream of the gene. (J:42995)

Expression

In Mice Carrying this Mutation:	3 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cebpa^tm1Gonz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 19 strains or lines available

References

• Original: J:42995 Lee YH, et al., Disruption of the c/ebp alpha gene in adult mouse liver. Mol Cell Biol. 1997 Oct;17(10):6014-22
• All: 27 reference(s)