Atp12a^tm1Ges
Targeted Allele Detail

Summary

• Symbol: Atp12a^tm1Ges
• Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide; targeted mutation 1, Gary E Shull
• MGI ID: MGI:2177160
• Synonyms: cHKA -
• Gene: Atp12a Location: Chr14:56602525-56626007 bp, + strand Genetic Position: Chr14, 28.19 cM, cytoband C3
• Alliance: Atp12a^tm1Ges page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45707
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A nenomycin selection cassette was inserted into exon 20. Northern blot and RT-PCR analysis on RNA derived from colon of homozygous mice demonstrated that aberrantly spliced transcripts were produced from this allele, but none of these produced a functional message. (J:45707)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Atp12a Mutation: 57 strains or lines available

References

• Original: J:45707 Meneton P, et al., Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice. J Clin Invest. 1998 Feb 1;101(3):536-42
• All: 10 reference(s)