Tg(Ckmm-cre)1Lrsn
Transgene Detail

Summary

• Symbol: Tg(Ckmm-cre)1Lrsn
• Name: transgene insertion 1, Nils-Goran Larsson
• MGI ID: MGI:2177173
• Synonyms: Ckm-cre, Ckmm-cre, MCK-cre
• Transgene: Tg(Ckmm-cre)1Lrsn Location: unknown Genetic Position: Chr10, Syntenic
• Alliance: Tg(Ckmm-cre)1Lrsn page

Heart histology of Tfam^tm1Lrsn/Tfam^tm1Lrsn Tg(Ckmm-cre)1Lrsn/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Ckmm-cre)1Lrsn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Ckm

• Mutation details: A 6.5 kb genomic DNA fragment of the Ckmm gene containing the promoter and enhancer 1, untranslated exon 1, 3kb of intron 1 including the enhancer 2 region, and the first 16 bp of exon 2 drives expression of cre. Cre is active in heart and skeletal muscle starting approximately at embryonic day 13. (J:51964)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ckm (species not specified) Summary of all recombinase alleles driven by Ckm.

Disease models

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:51964 Wang J, et al., Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet. 1999 Jan;21(1):133-7
• All: 32 reference(s)