Wap^tm1(cre)Arge
Targeted Allele Detail

Summary

• Symbol: Wap^tm1(cre)Arge
• Name: whey acidic protein; targeted mutation 1, Argiris Efstratiadis
• MGI ID: MGI:2177210
• Synonyms: Wap^cre
• Gene: Wap Location: Chr11:6585482-6588637 bp, - strand Genetic Position: Chr11, 4.61 cM
• Alliance: Wap^tm1(cre)Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70564
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Wap^tm1(cre)Arge expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Wap (MGI:98943)

• Mutation details: A cre gene followed by a neomycin selection cassette was inserted into the 5' noncoding region of the gene. Activity assays demonstrated that Cre recombinase activity was detectable in mammary gland of heterozygous and homozygous mice. (J:70564)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Wap (mouse) Summary of all recombinase alleles driven by Wap. Alliance mouse Wap gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Wap^tm1(cre)Arge

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wap Mutation: 33 strains or lines available

References

• Original: J:70564 Ludwig T, et al., Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene. 2001 Jul 5;20(30):3937-48
• All: 11 reference(s)