Brca2^tm2Arge
Targeted Allele Detail

Summary

• Symbol: Brca2^tm2Arge
• Name: breast cancer 2, early onset; targeted mutation 2, Argiris Efstratiadis
• MGI ID: MGI:2177211
• Synonyms: Brca2^flox, Brca2^flox3-4
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm2Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70564
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site followed by a neomycin selection cassette was inserted 5' to exon 3 and a single loxP site was inserted 3' to exon 4. (J:70564)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca2^tm2Arge

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:70564 Ludwig T, et al., Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene. 2001 Jul 5;20(30):3937-48
• All: 5 reference(s)