Brca2^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Brca2^tm1Brd
• Name: breast cancer 2, early onset; targeted mutation 1, Allan Bradley
• MGI ID: MGI:2177233
• Synonyms: Brca2^Brdm1, Brca2^KO, Brca2^tmBrd1
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39764
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-hprt minigene cassette replaced 2.8 kb of coding sequences corresponding to amino acids 626-1437 of the encoded protein. (J:39764)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Brca2^tm1Brd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:39764 Sharan SK, et al., Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments]. Nature. 1997 Apr 24;386(6627):804-10
• All: 7 reference(s)