Tg(KRT14-cre)8Brn
Transgene Detail

Summary

• Symbol: Tg(KRT14-cre)8Brn
• Name: transgene insertion 8, Anton Berns
• MGI ID: MGI:2177243
• Synonyms: K14cre, K14-Cre, Tg(K14-Cre)8Brn, Tg(KRT14-cre)1Brn
• Transgene: Tg(KRT14-cre)8Brn Location: unknown
• Alliance: Tg(KRT14-cre)8Brn page

Histological and Immunochemical examinaton of skin and teeth of Apc^tm2Rak/Apc^tm2Rak Tg(KRT14-cre)8Brn/0 mice at P12

Show the 10 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(KRT14-cre)8Brn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT14 (3861)

  Krt14

  (MGI:96688)

• Mutation details: This transgene expresses Cre recombinase under the control of a human keratin 14 promoter. This promoter is active in skin, salivary gland and mammary gland epithelium. Mammary gland epithelium recombination efficiency was estimated at a weak 5-30%. (J:73028)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT14 (human) Summary of all recombinase alleles driven by KRT14. Comparative matrix view of recombinase activities Alliance human KRT14 gene page

Disease models

Expression

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT14-cre)8Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

References

• Original: J:73028 Jonkers J, et al., Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001 Dec;29(4):418-25
• All: 129 reference(s)