Erbb2^tm2Cbm
Targeted Allele Detail

Summary

• Symbol: Erbb2^tm2Cbm
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 2, Carmen Birchmeier
• MGI ID: MGI:2177255
• Synonyms: erbB2^flox
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^tm2Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75421
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into intronic sequences flanking three exons. An adjacent loxP flanked neomycin selection cassette was removed in ES cells by transient Cre recombinase transfection prior to the production of chimeric mice. (J:75421)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:75421 Garratt AN, et al., A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol. 2000 Mar 6;148(5):1035-46
• All: 12 reference(s)