Erbb2^tm2.1Cbm
Targeted Allele Detail

Summary

• Symbol: Erbb2^tm2.1Cbm
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 2.1, Carmen Birchmeier
• MGI ID: MGI:2177256
• Synonyms: Erbb2^delta
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^tm2.1Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75421
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Erbb2^tm2Cbr in which the loxP flanked sequences were deleted in vivo by crossing mice carrying this allele to mice carrying the TgN(CMV-Cre)1Cgn transgene. (J:75421)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:75421 Garratt AN, et al., A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol. 2000 Mar 6;148(5):1035-46
• All: 2 reference(s)