Gpi1^a
Allele Detail

Summary

• Symbol: Gpi1^a
• Name: glucose-6-phosphate isomerase 1; a variant
• MGI ID: MGI:2177271
• Gene: Gpi1 Location: Chr7:33900755-33929761 bp, - strand Genetic Position: Chr7, 19.46 cM
• Alliance: Gpi1^a page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Not Applicable
• Mutation: Nucleotide substitutions
• Mutation details: This allele determines a slower migrating variant of the encoded enzyme and occurs in the wild and in strains 101/H, A/HeJ, AKR/J, BALB/cJ, C57BR/cdJ, C58/J, CE/J, DBA/2J, DE/J, DW/J, LP/J, MA/J, NZB, PL/J, P/J, RARF, RF/J, SJL/J, ST/bJ, and 129/J. Sequencing analysis identified four nucleotide differences between this allele and Gpi1^b. Two differences are silent, while a third difference at position nucleotide position 282 predicts an aspartate for the a allele and an asparagine for the b allele at amino acid position 94. A fourth difference in the 3' untranslated region was also noted. (J:28033)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 17 strains available Cell Lines: 0 lines available
• Carrying any Gpi1 Mutation: 71 strains or lines available

References

• Original: J:5141 DeLorenzo RJ, et al., Genetic control of two electrophoretic variants of glucosephosphate isomerase in the mouse (Mus musculus). Biochem Genet. 1969 Apr;3(2):151-62
• All: 18 reference(s)