Dntt^tm1Gfn
Targeted Allele Detail

Summary

• Symbol: Dntt^tm1Gfn
• Name: deoxynucleotidyltransferase, terminal; targeted mutation 1, Susan Gilfillan
• MGI ID: MGI:2177306
• Synonyms: TdT^-
• Gene: Dntt Location: Chr19:41017714-41047964 bp, + strand Genetic Position: Chr19, 34.32 cM
• Alliance: Dntt^tm1Gfn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:14407
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 4. RT-PCR and in situ hybridization analyses demonstrated that no detectable transcript was produced from this allele, and immunocytochemistry on thymocytes derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:14407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dntt Mutation: 34 strains or lines available

References

• Original: J:14407 Gilfillan S, et al., Mice lacking TdT: mature animals with an immature lymphocyte repertoire [published erratum appears in Science 1993 Dec 24;262(5142):1957]. Science. 1993 Aug 27;261(5125):1175-8
• All: 24 reference(s)