E2f3^tm1.1Gle
Targeted Allele Detail

Summary

• Symbol: E2f3^tm1.1Gle
• Name: E2F transcription factor 3; targeted mutation 1.1, Gustavo Leone
• MGI ID: MGI:2177317
• Synonyms: E2F3^f, E2f3^LoxP
• Gene: E2f3 Location: Chr13:30090558-30170046 bp, - strand Genetic Position: Chr13, 13.09 cM, cytoband A3.3
• Alliance: E2f3^tm1.1Gle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75726
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 3 and an additional loxP site was inserted downstream of the exon. Transient expression of Cre recombinase in ES cells prior to production of chimeric mice excised the neo cassette leaving exon 3 flanked by loxP sites. (J:73374)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f3 Mutation: 33 strains or lines available

References

• Original: J:75726 Leone G, et al., Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul;8(1):105-13
• All: 20 reference(s)