Tg(KRT5-cre/ERT2)2Ipc
Transgene Detail

Summary

• Symbol: Tg(KRT5-cre/ERT2)2Ipc
• Name: transgene insertion 2, I Pierre Chambon
• MGI ID: MGI:2177429
• Synonyms: CreERT2, K5-Cre-ER^T2, K5-CreERT2, Krt5^CreERT2, Tg(Krt1-5-cre/ERT2)2Ipc
• Transgene: Tg(KRT5-cre/ERT2)2Ipc Location: unknown
• Alliance: Tg(KRT5-cre/ERT2)2Ipc page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(KRT5-cre/ERT2)2Ipc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: This transgene expresses a tamoxifen-inducible form of cre recombinase under the control of the bovine KRT5 promoter in epidermal tissues. (J:69324)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT5 (cattle) Summary of all recombinase alleles driven by KRT5. Comparative matrix view of recombinase activities

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT5-cre/ERT2)2Ipc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:69324 Indra AK, et al., Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res. 1999 Nov 15;27(22):4324-7
• All: 59 reference(s)