Cftr^tm2Kth
Targeted Allele Detail

Summary

• Symbol: Cftr^tm2Kth
• Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 2, Kirk R Thomas
• MGI ID: MGI:2177535
• Synonyms: neo^r
• Gene: Cftr Location: Chr6:18170686-18322767 bp, + strand Genetic Position: Chr6, 8.1 cM, cytoband A3
• Alliance: Cftr^tm2Kth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29074
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted in intron 11 in reverse transcriptional orientation to the gene. This allele was generated as a control for Cftr^tm1Kth. (J:29074)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cftr Mutation: 98 strains or lines available

References

• Original: J:29074 Zeiher BG, et al., A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest. 1995 Oct;96(4):2051-64
• All: 1 reference(s)