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FusGt(U3NeoSV1)HO14Ggh
Gene trapped Allele Detail
Summary
Symbol: FusGt(U3NeoSV1)HO14Ggh
Name: fused in sarcoma; gene trap HO14, Geoffrey G Hicks
MGI ID: MGI:2177561
Synonyms: Fus -, TLS-
Gene: Fus  Location: Chr7:127565276-127581204 bp, + strand  Genetic Position: Chr7, 69.87 cM
Alliance: FusGt(U3NeoSV1)HO14Ggh page
Mutation
origin
Mutant Cell Line:  HO14
Germline Transmission:  Earliest citation of germline transmission: J:60213
Parent Cell Line:  D3H (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: U3NeoSV1
 
Mutation detailsThe mutation was generated by the random insertion of the gene trap vector U3NeoSV1 into exon 12 of the gene. RT-PCR and Northern blot analysis demonstrated that a truncated transcript is produced from this allele, and western blot analysis confirmed that low levels of a truncated protein were expressed from this allele. However, the expressed product is not expected to retain activity due to missing nucleic acid binding domains. (J:60213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fus Mutation:  48 strains or lines available
References
Original:  J:60213 Hicks GG, et al., Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat Genet. 2000 Feb;24(2):175-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory