Gad1^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Gad1^tm1Mrc
• Name: glutamate decarboxylase 1; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2177566
• Synonyms: GAD67 -
• Gene: Gad1 Location: Chr2:70392109-70432358 bp, + strand Genetic Position: Chr2, 41.63 cM, cytoband D
• Alliance: Gad1^tm1Mrc page

Cleft palate phenotype in Gad1^tm1Mrc/Gad1^tm1Mrc mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43954
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the first coding exon. RNase protection assays on RNA derived from brain of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:43954)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gad1 Mutation: 65 strains or lines available

References

• Original: J:43954 Condie BG, et al., Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11451-5
• All: 3 reference(s)