Alpl^tm1(cre)Nagy
Targeted Allele Detail

Summary

• Symbol: Alpl^tm1(cre)Nagy
• Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 1, Andras Nagy
• MGI ID: MGI:2177588
• Synonyms: Alpl-cre, TNAP-Cre, TNAP/Cre, TNAP^Cre
• Gene: Alpl Location: Chr4:137469044-137523695 bp, - strand Genetic Position: Chr4, 70.02 cM
• Alliance: Alpl^tm1(cre)Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60934
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Alpl^tm1(cre)Nagy expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Alpl (MGI:87983)

• Mutation details: An IRES-cre gene followed by a neomycin gene was inserted into exon 6 of the gene. This allele expresses Cre recombinase in primordial germ cells. (J:60934)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Alpl (mouse) Summary of all recombinase alleles driven by Alpl. Comparative matrix view of recombinase activities Alliance mouse Alpl gene page

Expression

In Mice Carrying this Mutation:

27 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Alpl Mutation: 352 strains or lines available

References

• Original: J:60934 Lomeli H, et al., Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells. Genesis. 2000 Feb;26(2):116-7
• All: 85 reference(s)