Nlk^tm1Tbo
Targeted Allele Detail

Summary

• Symbol: Nlk^tm1Tbo
• Name: nemo like kinase; targeted mutation 1, Thomas Boehm
• MGI ID: MGI:2177606
• Synonyms: Nlk-, Nlk^m1Boe
• Gene: Nlk Location: Chr11:78457994-78588199 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Nlk^tm1Tbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73353
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of an IRES-beta-galactosidase-neomycin cassette into exon 5 disrupted the gene and placed expression of lacZ under control of the endogenous promoter. (J:73353)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlk Mutation: 46 strains or lines available

References

• Original: J:73353 Kortenjann M, et al., Abnormal bone marrow stroma in mice deficient for nemo-like kinase, Nlk. Eur J Immunol. 2001 Dec;31(12):3580-7
• All: 1 reference(s)