Gabrg2^tm1Lusc
Targeted Allele Detail

Summary

• Symbol: Gabrg2^tm1Lusc
• Name: gamma-aminobutyric acid type A receptor, subunit gamma 2; targeted mutation 1, Bernhard Luscher
• MGI ID: MGI:2177608
• Synonyms: gamma2^-, gamma2⁰
• Gene: Gabrg2 Location: Chr11:41801030-41891684 bp, - strand Genetic Position: Chr11, 24.8 cM
• Alliance: Gabrg2^tm1Lusc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28662
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette replaced a genomic fragment containing exon 8. (J:28662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabrg2 Mutation: 41 strains or lines available

References

• Original: J:28662 Gunther U, et al., Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7749-53
• All: 17 reference(s)