Gabrb2^tm1Twr
Targeted Allele Detail

Summary

• Symbol: Gabrb2^tm1Twr
• Name: gamma-aminobutyric acid type A receptor subunit beta 2; targeted mutation 1, Thomas W Rosahl
• MGI ID: MGI:2177613
• Synonyms: beta2 -
• Gene: Gabrb2 Location: Chr11:42310584-42519855 bp, + strand Genetic Position: Chr11, 25.08 cM
• Alliance: Gabrb2^tm1Twr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69290
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 7 was replaced with a loxP flanked neomycin selection cassette. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:69290)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabrb2 Mutation: 44 strains or lines available

References

• Original: J:69290 Sur C, et al., Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci. 2001 May 15;21(10):3409-18
• All: 6 reference(s)