Fus^{tm1(DDIT3)Dron}
Targeted Allele Detail

Summary

• Symbol: Fus^{tm1(DDIT3)Dron}
• Name: fused in sarcoma; targeted mutation 1, David Ron
• MGI ID: MGI:2177655
• Synonyms: TLS -, Tls.m2, TLS-NEO
• Gene: Fus Location: Chr7:127565276-127581204 bp, + strand Genetic Position: Chr7, 69.87 cM
• Alliance: Fus^{tm1(DDIT3)Dron} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75732
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A knock-in cassette containing a loxP-flanked neomycin gene followed by a human DDIT3 gene replaced exons 8 and 9. This allele expresses a fusion protein of FUS and Neo in which the neomycin sequences replace the RNA-binding C-terminal portion of the gene; the inserted DDIT3 gene is not expressed. (J:75732)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fus Mutation: 48 strains or lines available

References

• Original: J:75732 Kuroda M, et al., Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5025-30
• All: 2 reference(s)