Gck^tm1.2Mgn
Targeted Allele Detail

Summary

• Symbol: Gck^tm1.2Mgn
• Name: glucokinase; targeted mutation 1.2, Mark A Magnuson
• MGI ID: MGI:2177710
• Synonyms: gk^del
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^tm1.2Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51826
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Gck^tm1Mgn in which all the loxP flanked sequences including exons 9 and 10 as well as the neomycin selection cassette were deleted by injecting heterozygous fertilized eggs with a plasmid expressing Cre recombinase. Progeny were screened for the allele in which all sequences were deleted. (J:51826)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 64 strains or lines available

References

• Original: J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
• All: 2 reference(s)