Srebf1^tm1Jdh
Targeted Allele Detail

Summary

• Symbol: Srebf1^tm1Jdh
• Name: sterol regulatory element binding transcription factor 1; targeted mutation 1, Jay D Horton
• MGI ID: MGI:2177773
• Synonyms: allele A, srebp-1
• Gene: Srebf1 Location: Chr11:60089915-60113407 bp, - strand Genetic Position: Chr11, 37.81 cM
• Alliance: Srebf1^tm1Jdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43570
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the middle of exon 2. Western blot analysis on membrane and nuclear extracts of liver from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:43570)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srebf1 Mutation: 55 strains or lines available

Notes

ES cell line = JH1 (129S7/SvEvBrd) or SM1 (129S6/SvEvTac).

References

• Original: J:43570 Shimano H, et al., Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene [see comments]. J Clin Invest. 1997 Oct 15;100(8):2115-24
• All: 15 reference(s)