Il11ra1^tm1Gos
Targeted Allele Detail

Summary

• Symbol: Il11ra1^tm1Gos
• Name: interleukin 11 receptor subunit alpha 1; targeted mutation 1, Achim Gossler
• MGI ID: MGI:2177774
• Synonyms: Il11ra1^{TgH(PGKneo)7Gos}, IL-11Ralpha^TgH(PGK-neo)
• Gene: Il11ra1 Location: Chr4:41760443-41769473 bp, + strand Genetic Position: Chr4, 21.94 cM
• Alliance: Il11ra1^tm1Gos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48920
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting event resulted in the insertion of a neomycin resistance gene into intron 8, followed by a truncated, promoterless Il11ra1 gene lacking exons 2-13. Northern blot experiments on RNA derived from kidney of homozygous mice demonstrated that an aberrant transcript was produced from this allele. It was a size consistent with the splicing around the neo cassette to produce a transcript that contains exon 1-8 fused to exons 2-13. Western blot analysis on kidney extracts confirmed that an aberrantly sized protein was expressed from this allele, although at lower levels than Il11ra1^tm2Gos. (J:48920)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il11ra1 Mutation: 37 strains or lines available

References

• Original: J:48920 Bilinski P, et al., Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Genes Dev. 1998 Jul 15;12(14):2234-43
• All: 2 reference(s)