Il11ra1^tm1Wehi
Targeted Allele Detail

Summary

• Symbol: Il11ra1^tm1Wehi
• Name: interleukin 11 receptor subunit alpha 1; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:2177778
• Synonyms: IL11Ra -, IL-11Ralpha1^-
• Gene: Il11ra1 Location: Chr4:41760443-41769473 bp, + strand Genetic Position: Chr4, 21.94 cM
• Alliance: Il11ra1^tm1Wehi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42921
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 9-12 and part of 8 and 13. Northern blot analysis on RNA derived from kidney and testis of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:42921)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il11ra1 Mutation: 37 strains or lines available

References

• Original: J:42921 Nandurkar HH, et al., Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood. 1997 Sep 15;90(6):2148-59
• All: 40 reference(s)