Evx1^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Evx1^tm1Mrc
• Name: even-skipped homeobox 1; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2177782
• Synonyms: evx1^-
• Gene: Evx1 Location: Chr6:52290483-52295363 bp, + strand Genetic Position: Chr6, 25.44 cM
• Alliance: Evx1^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20014
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a DNA segment coding for the first amino acid residues of the first helix of the homeobox domain and part of intron 2. (J:20014)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Evx1 Mutation: 18 strains or lines available

Notes

These mice have a second closely linked mutation that is thought to underlie the observed early embryonic lethality, and therefore it may not be due to the Evx1 mutation. See the discussion in the following reference: J:70192.

References

• Original: J:20014 Spyropoulos DD, et al., Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes Dev. 1994 Aug 15;8(16):1949-61
• All: 2 reference(s)