Gata6^tm1Msp
Targeted Allele Detail

Summary

• Symbol: Gata6^tm1Msp
• Name: GATA binding protein 6; targeted mutation 1, Michael S Parmacek
• MGI ID: MGI:2177785
• Synonyms: Gata6^-
• Gene: Gata6 Location: Chr18:11052510-11085636 bp, + strand Genetic Position: Chr18, 5.63 cM
• Alliance: Gata6^tm1Msp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51304
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 4 and 5, which encode the zinc finger domains of the encoded protein. In situ hybridization experiments on homozygous embryos demonstrated that no detectable transcript was produced from this allele. (J:51304)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata6 Mutation: 35 strains or lines available

References

• Original: J:51304 Morrisey EE, et al., GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev. 1998 Nov 15;12(22):3579-90
• All: 6 reference(s)