Bsg^tm1Tmu
Targeted Allele Detail

Summary

• Symbol: Bsg^tm1Tmu
• Name: basigin; targeted mutation 1, Takashi Muramatsu
• MGI ID: MGI:2177802
• Synonyms: Bsg^-
• Gene: Bsg Location: Chr10:79540325-79547803 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Bsg^tm1Tmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46376
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced 200 bp of the first exon, containing sequences encoding the signal peptide. Northern blot analysis on RNA derived from testis and cerebrum of homozygous mice confirmed that no detectable transcript was produced from this allele. Western blot analysis on extracts derived form testis and uterus of homozygous mice confirmed that no detectable protein is expressed from this allele. (J:46376)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bsg Mutation: 17 strains or lines available

References

• Original: J:46376 Igakura T, et al., A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Dev Biol. 1998 Feb 15;194(2):152-65
• All: 26 reference(s)