Kmt2a^tm1Tok
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1Tok
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Toshihisa Komori
• MGI ID: MGI:2177818
• Synonyms: MLL-, Mll^mu
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1Tok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48502
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic segment containing exons 12-14. Aberrant transcripts were produced from this allele that are predicted to produce a nonfunctional protein, if any. (J:48502)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:48502 Yagi H, et al., Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Blood. 1998 Jul 1;92(1):108-17
• All: 6 reference(s)