Fn1^tm2Hyn
Targeted Allele Detail

Summary

• Symbol: Fn1^tm2Hyn
• Name: fibronectin 1; targeted mutation 2, Richard Hynes
• MGI ID: MGI:2177825
• Synonyms: FN.B1, FN^B1
• Gene: Fn1 Location: Chr1:71624679-71692359 bp, - strand Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
• Alliance: Fn1^tm2Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36210
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.6 kb genomic fragment containing exon 3b was replaced by a neomycin resistance cassette. The encoded protein was not detectable in immunoprecipitations from cultures of homozygous mutant E7.5 embryos. (J:36210)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fn1 Mutation: 130 strains or lines available

References

• Original: J:36210 Georges-Labouesse EN, et al., Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn. 1996 Oct;207(2):145-56
• All: 1 reference(s)