Fn1^tm3Hyn
Targeted Allele Detail

Summary

• Symbol: Fn1^tm3Hyn
• Name: fibronectin 1; targeted mutation 3, Richard Hynes
• MGI ID: MGI:2177826
• Synonyms: FN.B2, FN^B2
• Gene: Fn1 Location: Chr1:71624679-71692359 bp, - strand Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
• Alliance: Fn1^tm3Hyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36210
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A partial cDNA fragment corresponding to sequences of exons III7b, EIIIB and III8a replaced the genomic fragment containing these three exons. The encoded protein was not detectable in immunoprecipitations from cultures of homozygous mutant E7.5 embryos. (J:36210)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fn1 Mutation: 130 strains or lines available

References

• Original: J:36210 Georges-Labouesse EN, et al., Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn. 1996 Oct;207(2):145-56
• All: 1 reference(s)