Mapk14^tm1Mka
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1Mka
• Name: mitogen-activated protein kinase 14; targeted mutation 1, Michael Karin
• MGI ID: MGI:2177830
• Synonyms: p38alpha -
• Gene: Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63425
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the genomic sequence at a position corresponding to codon 97. Western blot and immunoprecipitation experiments confirmed that no detectable protein was expressed from this allele. (J:63425)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 43 strains or lines available

References

• Original: J:63425 Tamura K, et al., Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21;102(2):221-31
• All: 7 reference(s)